HUM00202034

Women and men are needed to help identify the effects of 6-weeks of non-weight bearing exercise on diabetic foot ulcer healing. 

Who can participate?

• Type 2 diabetics (women and men) possessing a diabetic wound/ulcer free of infection
• Non-smoker 
• English speaking
• Not currently pregnant or lactating

You will undergo/receive:

• Medical history and health examination
• Regular wound assessment
• Peripheral vascular function testing 
• Glucose testing
• Body composition assessment
• Free Parking
• Up to $350 upon completion of the study

STUDY DETAILS:
Preliminary Screening – Before participating in the study, you will undergo screening at the School of Kinesiology (SKB) consisting of three visits. The first appointment should take about 4.5 hours to complete and will include a resting electrocardiogram (EKG), oral glucose tolerance test, body composition assessment, graded exercise stress test, basic blood draw, urine pregnancy test (for pre-menopausal women), and detailed medical history survey. The second appointment should take about 3 hours to complete and will include a peripheral vascular assessment in response to exercise. The third appointment should take about 1.5 hours to complete and will include a peripheral neuropathy assessment.
If you are deemed eligible based on the results of the preliminary screening, you will be enrolled into our study. You will be randomly assigned to either the Aerobic Exercise (AE) or Control group after visit 2. Both groups will also receive standard diabetes care. The study consists of three (3) distinct phases: Baseline Testing, 6-Week Study Period, and Post Testing.

1. Baseline Testing: We want to assess your current level of health and fitness. We will measure your: body composition, peripheral vascular health, peripheral nerve health, blood sugar control, and response to an acute exercise test. These tests will involve blood sampling.
2. 6-Week Study Period: If you are assigned to the AE group, you will undergo 6 weeks of supervised exercise training (3x/week) at the University of Michigan School of Kinesiology (SKB). You will be performing one-legged aerobic-type exercise (i.e., cycling). Heart rate and blood pressure will be monitored during these exercise sessions. The AE group will also be asked to return at week 3 to re-evaluate your vascular response to exercise. If you are assigned to the Control group, you will be asked to resume your normal activities throughout the 6-week study period. 
3. Post Testing: We will perform all the same tests that we did at baseline testing described above in order to see how your health and fitness has changed after 6 weeks of exercise training or standard care.

If interested please fill out our pre-screening questionnaire: umich.qualtrics.com/jfe/form/SV_ehcQcJUND6KVMbk