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Integrative Molecular Genetics Laboratory

Discovering how exercise maintains the structure and integrity of DNA
Dr. Ludlow (left) and student in the Integrative Molecular Genetics Lab
About

The Integrative Molecular Genetics Laboratory aims to understand telomere biology in stem cells, aging, and cancer. Our research focuses on how telomeres (the protective caps at the end of each DNA strand) and telomerase (an enzyme that maintains and lengthens telomeres) are regulated and how they become dysfunctional in aging and cancer. By understanding telomere biology, we hope to develop exercise and diet interventions and drug and small molecule therapies to manipulate telomere biology in aging and cancer.

Director(s)

Andrew Ludlow, PhD

atludlow@umich.edu
Download CV Michigan Research Expert Profile

Member(s)

PhD Student(s)

Alexander Ahn

,
jungahn@umich.edu

Jeongjin Kim

,
snujjk@umich.edu

Projects

Telomere length induced changes in gene expression: mechanistic role in metabolism and aging
Cancer, telomeres and lifestyle (diet and exercise): Is there a connection?
Regulation and manipulation of hTERT/telomerase splicing in cancer cells
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