Exercise and Fat Metabolism (CAT) Study
The purpose of this study is to measure the effects of exercise training on the structure and metabolic function of fat tissue from overweight/obese adults.
This research is limited to weight stable (± 6 pounds in the past 6 months), overweight/obese men and women between the ages of 18-40 years old. For this study, overweight/obesity is measured by a Body Mass Index (BMI) equal to 27-35 kg/m2. We will recruit two different groups matched for BMI: 1) individuals who do not regularly exercise (i.e. have not completed any regularly planned exercise for the past 1 year or more), and 2) those who exercise regularly (i.e. at least 4 days/week of aerobic/cardiovascular exercise for ≥30 min/session at moderate-vigorous intensities). All participants must not have any evidence or history of cardiovascular or metabolic disease and must not take any medications known to affect inflammation, lipid or glucose metabolism. Tobacco or e-cigarette users will be excluded. Female participants must not be pregnant, actively breastfeeding, or menopausal and must have regularly occurring menses. No racial or ethnic group will be excluded.
You will be contacted to set up a remote screening appointment where the details of the study will be discussed with a study team member complete the following questionnaires:
- Detailed Medical History Questionnaire
- American College of Sports Medicine (ACSM) / American Heart Association (AHA) Health/Fitness Facility Pre-participation Questionnaire
- Godin Physical Activity Assessment
If you agree to participate in the study, you will be scheduled for an in-person physical screening appointment at the “Clinical Suite” located in the School of Kinesiology at the University of Michigan. At this appointment we will complete the following:
- Height, weight, and blood pressure measurements
- Bioelectrical Impedance Analysis (BIA) to test your body composition
- Exercise Fitness Test*
*During the COVID-19 pandemic era, prior to the exercise fitness test you will be required to take a COVID-19 test 48-96 hours before this appointment. Only subjects with a negative COVID-19 test will be eligible to continue to participate.
If eligible to participate in the study after completing the physical screening appointment, you will be asked to return to the Substrate Metabolism Laboratory to participate in an experimental trial appointment.
This appointment will take place at the School of Kinesiology’s “Clinical Suite”. You will be required to eat a standardized dinner at 6:00 PM and standardized snack at 10:00 PM the evening before your Experimental Trial Appointment. After eating your snack, you will “fast” overnight -- no other food or beverages (besides water) will be permitted. The next morning, after an overnight fast, you will arrive to the “Clinical Suite” at 7:00 AM. After 30 min of quiet rest we will obtain an abdominal fat tissue biopsy sample. After the biopsy procedure, you will complete an Oral Glucose Tolerance Test (OGTT). Once the OGTT is complete, you will be provided a meal and discharged. This appointment will take about 4.5 hours to complete
You will receive $100 for completion of the entire study. No compensation will be given for the physical screening appointment/testing. If you do not complete the entire study you will be compensated at a rate of $10 per hour for the time that you have participated in the experimental trial, this does not include the time spent during the physical screening appointment.
To sign up to screen for this study, select “Exercise and Fat Metabolism (CAT) Study” on our general online screening questionnaire (myumi.ch/51VM2)