Substrate Metabolism Laboratory

“The Substrate Metabolism Laboratory conducts research centered around diet and exercise, attempting to discover how these factors affect the risk and prevalence of metabolic diseases such as Type 2 diabetes. The health benefits for exercising are well-known, but what is still unclear are the actual mechanisms of diet and exercise that produce healthier lives. By studying and understanding these mechanisms, we will be able to target specific training programs or medications designed to reduce the risk of disease.”
Dr. Jeff Horowitz, Director and Professor of Movement Science

Substrate Metabolism Laboratory

Contact

Address: 
CCRB 1210
401 Washtenaw Ave.
Ann Arbor, MI 48109-2214
(734) 647-3354
(734) 936-1925

Director

Projects

Fatty Metabolism and Insulin Sensitivity Study

Purpose: To compare the relationship between systemic fatty acid availability and insulin sensitivity in obese adults.

To learn more about this study, and to sign up to be a potential subject for it, read the full description on the Substrate Metabolism Laboratory Studies page

Effect of Exercise on Metabolic Health Study

Purpose: One of the main objectives of this study will be to assess potential differences in important risk factors associated with Metabolic Syndrome in overweight adults who do not participate in a regular exercise program compared with overweight individuals who do exercise regularly.  In addition, we will determine the effects of a single, modest session of exercise on the body’s ability to control blood sugar and regulate fat metabolism in obese sedentary adults vs. obese adults who live a physically active lifestyle. Our study focuses on identifying mechanisms responsible for improved insulin action related to regular exercise and to provide novel targets for preventing and treating type 2 diabetes.

To learn more about this study, and to sign up to be a potential subject for it, read the full description on the Substrate Metabolism Laboratory Studies page.

Exercise Study

Purpose: The primary purpose of this study is to examine the effects of exercise on key risk factors associated with Metabolic Syndrome (e.g., glucose tolerance, blood lipid profile, and blood pressure) and changes in subcutaneous fat tissue structure and metabolic function in adults.

To learn more about this study, and to sign up to be a potential subject for it, read the full description on the Substrate Metabolism Laboratory Studies page

Chronic vs. Acute Exercise Study

Purpose: The primary purpose of this study is to examine the effects of chronic exercise training and an acute session of exercise on key risk factors associated with Metabolic Syndrome (e.g., glucose tolerance, blood lipid profile, and blood pressure) and alterations in subcutaneous adipose tissue structure and metabolic function in overweight adults.

To learn more about this study, and to sign up to be a potential subject for it, read the full description on the Substrate Metabolism Laboratory Studies page.

Exercise and Overeating Study

PURPOSE: The primary purpose of this study is to examine the effects of 1-week of overeating on important clinical metabolic health outcomes (e.g., glucose tolerance, blood lipid profile, and blood pressure) and factors regulating the structure and metabolic function of fat tissue. This study will determine how regular exercise during this overeating period impacts these responses.

To learn more about this study, and to sign up to be a potential subject for it, read the full description on the Substrate Metabolism Laboratory Studies page.

High Intensity Interval Training (HIIT) Study

PURPOSE: Our overall objectives are to:

  1. Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the whole-body, tissue, and cellular levels; 
  2. Systematically compare different HIIT regimens to help identify effective “doses” of HIIT that may be optimal for improving metabolic health in obese adults; and
  3. Assess the ability/willingness of obese subjects to adhere to a long-term HIIT program.

Findings from these studies will greatly expand our understanding about the effects of HIIT on metabolic health, and will provide valuable information for development of programs aimed at maximizing key metabolic benefits of exercise.

To learn more about this study, and to sign up to be a potential subject for it, read the full description on the Substrate Metabolism Laboratory Studies page.

Protection Against Insulin Resistance (PAIR) Study

PURPOSE: Insulin resistance is a major contributor to the development of several obesity-related diseases. Despite the common link between obesity and insulin resistance, as many as one-third of obese adults appear to be “protected” against insulin resistance. Our preliminary findings indicate that insulin resistance can vary considerably even in a population of obese adults who are very similar in terms of the magnitude and distribution of their adiposity. The overall goal of this project is to identify factors that “protect” some obese adults from becoming insulin resistant. Identifying mechanisms that help protect some obese adults from developing insulin resistance could lead to novel, targeted therapeutic and/or preventative strategies for obese adults who are insulin resistant.

To learn more about this study, and to sign up to be a potential subject for it, read the full description on the Substrate Metabolism Laboratory Studies page.

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