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Jeffrey Horowitz, Ph.D.

Associate Professor, Movement Science

• Areas of Interest
• Educational Background
• Research
• Teaching
• Honors and Awards
• Professional Affiliation
• Selected Publications
• Selected Projects/Grants

4745C CCRB
401 Washtenaw Ave.
Ann Arbor, MI 48109-2214
Phone: (734) 647-1076
Fax: (734) 936-1925
jeffhoro@umich.edu

Office Hours (Spring Summer 2008):
Please contact for an appointment

Full vita>>

Laboratory:

• Substrate Metabolism Laboratory (SML)
• Center for Exercise Research (CXR)

Areas of Interest

Short Description: regulation of fuel mobilization and oxidation and the impact of this regulation on human health

Dr. Horowitz is an exercise physiologist primarily interested in the regulation of fat and carbohydrate metabolism. More specifically, his interests are focused on the regulation of fuel (substrate) mobilization and oxidation and how exercise influences this regulation. The scope of his research is aimed at determining the impact of alterations in substrate metabolism on important health issues such as obesity, diabetes, heart disease, and advancing age.

Educational Background

University of Texas, Austin, TX
Ph.D., Exercise Physiology, 1996

University of Texas, Austin, TX
M.A., Exercise Physiology, 1992

University of Iowa, Iowa City, IA
B.S.E., Biomedical Engineering, 1989

Research

• "Dietary fatty acid composition and obesity-related metabolic abnormalities"
• "Exercise dose response for improving insulin sensitivity"
• "Fatty acid metabolism and insulin sensitivity after exercise in obesity"
• "Physiological importance of growth hormone pulsatility"
• "Growth Hormone as a determinant of weight regulation"

Teaching

MOVESCI 340. Exercise Physiology

KINESLGY 511. Experimental Courses in Exercise Physiology

KINESLGY 540. Graduate Seminar in Exercise Physiology

KINESLGY 600. Graduate Seminar in Movement Science

* Movement Science courses are for undergraduate credit; Kinesiology courses are for graduate credit.


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Honors and Awards

Professional Affiliations

Selected Publications

Horowitz JF. “Exercise-induced alterations in muscle lipid metabolism improve insulin sensitivity.” Exerc Sport Sci Rev. 35(4):192-196, 2007.

Schenk S and JF Horowitz. “Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance”. J. Clin Invest. 117(6): 1690-1698, 2007.

Knuth, ND and JF Horowitz. “The elevation of ingested lipids within plasma chylomicrons is prolonged in men compared with women”. J Nutr. 136:1498-1503, 2006.

Schenk S and JF Horowitz. “Co-immunoprecipitation of FAT/CD36 and carnitine palmitoyl transferase-I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training”. Am J Physiol Endocrinol Metab. 291(2):E254-E260, 2006.

Horowitz JF. “Adipose tissue lipid mobilization during exercise”. In: M Hargreaves and LL Spriet eds. Metabolic responses to exercise. Champaign, Il. Human Kinetics. pps. 89-104, 2006.

Horowitz JF, AE Kaufman, AK Fox, and MP Harber. "Energy deficit without reducing dietary carbohydrate alters resting carbohydrate oxidation and fatty acid availability". J Appl Physiol. 98(5):1612-1618, 2005.

Harber MP, S Schenk, AL Barkan and JF Horowitz . "Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis". J Clin Endocrinol Metab. 90:5175-5181, 2005.

Harber MP, S Schenk, AL Barkan and JF Horowitz . "Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction". Am J Physiol Endocrinol Metab. 289:E306-E312, 2005.

Schenk S, JN Cook, AE Kaufman, and JF Horowitz. "Post-exercise insulin sensitivity is not impaired after an overnight lipid infusion". Am. J. Physiol. 288(3):E519-E525, 2005

Fox AK, AE Kaufman, and JF Horowitz. "Adding fat calories to meals after exercise does not alter insulin sensitivity". J. Appl. Physiol. 97:11-16, 2004.

Horowitz, JF. "Fatty acid mobilization from adipose tissue during exercise." Trends Endocrinol. Metab. 14(8): 386-392, 2003.

Mittendorfer, B, JF Horowitz, and S Klein. "Effect of gender on lipid kinetics during moderate intensity endurance exercise in untrained subjects." Am J. Physiol. 283:E58-E65, 2002.

Patterson, BW, JF Horowitz, G Wu, M Watford, SW Coppack, and S Klein. "Regional muscle and adipose tissue amino acid metabolism in lean and obese women." Am J Physiol 282:E931-E936, 2002.

Mittendorfer, B. Horowitz, JF, Klein, S. "Gender differences in lipid and glucose kinetics during short-term fasting." Am J Physiol. 281(6):E1333-E1339, 2001.

Horowitz, JF, and S. Klein. "Differences in acetate recovery factor between groups may interfere with tracer estimates of fat oxidation" — Letters to the Editor. J. Appl. Physiol. 90:2520-2521, 2001.

Horowitz, J.F., S.W. Coppack, and S. Klein. "Whole-body and adipose tissue glucose metabolism in response to short-term fasting in lean and obese women." Am. J. Clin. Nutr.73:517-522, 2001.

Horowitz, J.F. and S. Klein. "Oxidation of non-plasma fatty acids during exercise is increased in women with abdominal obesity." J. Appl. Physiol. 89:2276-2282, 2000.

Horowitz, J.F., T. C. Leone, D. P. Kelly, and S. Klein. "Effect of endurance training on lipid metabolism in women: a role for PPARa in the metabolic response to training." Am. J. Physiol. Endocrinol. Metab. 279: E348-E355, 2000.

Horowitz, J.F. and S. Klein. "Whole-body and abdominal subcutaneous adipose tissue lipolytic sensitivity to epinephrine is suppressed in women with upper-body obesity." Am. J. Physiol. 278:E1144-E1152, 2000.


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Selected Projects/Grants

2005-2010 National Institutes of Health “Growth hormone as a determinant of weight regulation” (Principle Investigator) $2,100,000.

2004-2009. National Institutes of Health. "Physiological importance of growth hormone pulsatility." (Co-Principal Investigator). $1,500,000.

2007-2009. Robert C and Veronica Atkins Foundation "Dietary fatty acid composition and obesity-related metabolic abnormalities." (Principal Investigator). $450,000.

2003-2006. American Diabetes Association. "Fatty acid metabolism and insulin sensitivity: The role of endurance exercise training." (Principal Investigator) $430,000.

2003. Michigan Diabetes Research Training Center. "Role of elevated fatty acid availability on skeletal muscle fatty acid metabolism and the exercise induced increase in insulin sensitivity." (Principal Investigator). $35,000.

2002-05. Michigan Life Sciences Corridor. "Improving muscle power and mobility of elderly men and women." (Co-Principal Investigator). $4,000,000.

2001. Rackham Faculty Grant, the University of Michigan. "Role of acute physical activity and diet on lipid metabolism." $15,000.

2001. Michigan Phoenix Memorial Project Award. "Role of acute physical activity and diet on lipid metabolism." $10,000.

1998-1999. National Institutes of Health (individual NRSA). "Exercise and lipid metabolism in obese women." $30,160.