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Gregory Cartee, Ph.D.

Professor, Movement Science

• Areas of Interest
• Educational Background
• Research
• Teaching
• Honors and Awards
• Professional Affiliations and Service
• Selected Publications
• Selected Grants
• Links

4745F CCRB
401 Washtenaw Ave.
Ann Arbor, MI 48109-2214
Phone: (734) 615-3458
Fax: (734) 936-1925
gcartee@umich.edu

Office Hours (Spring Summer 2008):
Please contact for an appointment

Full vita>>

Laboratories / Research Centers:

• Muscle Biology Laboratory
• Center for Exercise Research
• Claude D. Pepper Older Americans Independence Center
• Nathan Shock Center of Excellence in Aging Research
• Institute of Gerontology
• Michigan Diabetes Research and Training Center
• Michigan Metabolomics and Obesity Center

Areas of Interest

Short Description: Exercise, diet, and age effects on insulin signaling and glucose metabolism in skeletal muscle

The research in the Muscle Biology Laboratory is focused on skeletal muscle metabolism. We are especially interested in the modulation of glucose transport by exercise and calorie restriction (consuming 60% of ad libitum uptake), and how these interventions are influenced by advancing age. Each of these interventions can lead to a substantial improvement in skeletal muscle insulin sensitivity, which is a significant benefit for health. The improved insulin sensitivity after a bout of exercise facilitates the restoration of muscle glycogen stores, thereby improving the capacity for subsequent exercise. Our long-term goals are to understand the specific mechanisms whereby these physiological interventions lead to improved insulin sensitivity.

Educational Background

Washington University School of Medicine, St. Louis, MO
Postdoctoral Fellowship, 1985-1988

University of Texas, Austin TX
Ph.D., Exercise Physiology, 1985
"The Effects of Age and Endurance Training on the Oxidative Metabolism of Fisher 344 Rats."

Florida State University, Tallahassee, FL
M.S., Exercise Physiology, 1981

University of Georgia, Athens, GA
B.S., Health and Physical Education, 1979

Research

• Mechanisms for Increased Insulin-Stimulated Glucose Transport after Acute Exercise
• Mechanisms for Improved Insulin Sensitivity with Calorie Restriction
• In Vitro Simulation of Calorie Restriction: Effects on Skeletal Muscle Insulin Signaling and Action

Teaching

MOVESCI 449 / KINESLGY 449.* Laboratory Rotation in Exercise Physiology

KINESLGY 545. Metabolic Responses to Exercise.
SYLLABUS

KINESLGY 600. Seminar in Movement Science

* Movement Science courses are for undergraduate credit; Kinesiology courses are for graduate credit.

Honors and Awards

Professional Affiliations and Service

Selected Publications

Publications in Refereed Journals

Arias, E.B and G.D. Cartee. “In vitro simulation of calorie restriction-induced decline in glucose and insulin leads to increased insulin-stimulated glucose transport in rat skeletal muscle.” Am. J. Physiol.(Endocrinol. Metab.). 293: E1782-E1788, 2007.

Arias, E.B., J. Kim, K. Funai and G.D. Cartee. “Prior exercise increases Akt Substrate of 160 kDa phosphorylation in rat skeletal muscle”. Am. J. Physiol. (Endocrinol. Metab.) 292: E1191-E1200, 2007.

Cartee, G.D. and J.F. Wojtaszewski. “Role of Akt Substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport”. Appl. Physiol, Nutr. Metab. 32: 557-556, 2007.

Kim, J., E.B. Arias and G.D. Cartee. “Effects of prior swim exercise on glucose uptake in isolated skeletal muscles from mice,” J. Physiol. Sci. 56: 305-312, 2006.

Hamada, T., E.B. Arias and G.D. Cartee. “Increased submaximal insulin-stimulated glucose uptake in mouse skeletal muscle after treadmill exercise.” J. Appl. Physiol. 101: 1368-1376, 2006.

Bruss, M.D., E.B. Arias, G.E. Lienhard, and G.D. Cartee. "Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity." Diabetes. 54: 41-50, 2005.

McCurdy, C.E, R.T. Davidson and G.D. Cartee. "Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle." Am. J. Physiol.(Endocrinol. Metab.). 288: E996-E1001, 2005.

McCurdy, C.E. and G.D. Cartee. "Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle." Diabetes. 54: 1349-1356, 2005.

Sancho, R., J. Kim and G.D. Cartee. "Decreased contraction-stimulated glucose transport in isolated epitrochlearis muscles of pregnant rats". J. Appl. Physiol. 98: 1021-1027, 2005.

Kim, J., R.S. Solis, E.B. Arias, and G.D. Cartee. "Post-contraction insulin sensitivity: Relationship with contraction protocol, glycogen concentration and 5'AMP-activated protein kinase phosphorylation". J. Appl. Physiol. 96: 575-583, 2004.

Arias, E.B., J. Kim, and G.D. Cartee. "Prolonged incubation in PUGNAC results in increased protein O-linked glycosylation and insulin resistance in rat skeletal muscle". Diabetes. 53: 921-930, 2004.

McCurdy, C.E., R.T. Davidson, and G.D. Cartee. "Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle". Am. J. Physiol.(Endocrinol. Metab.) 48: E693-E700, 2003.

Selected Grants

Extramural:

2007. National Institutes of Health. Principal Investigator. “Aging, Calorie Restriction and Insulin Signaling.” ($1,541,912).

2007. National Institutes of Health. Principal Investigator. “Aging, Calorie Restriction and Insulin Signaling.” Supplement ($76,000).

2006. National Institutes of Health. Principal Investigator. “Skeletal Muscle Glucose Transport: Exercise and Insulin.” ($1,532,000).

2004. National Institutes of Health. Principal Investigator. "In Vitro Models for Insulin sensitivity in Rat Skeletal Muscle: Pilot Project." (Claude Pepper Older American's Independence Center. Jeffrey Halter, MD., PI). ($40,000).

2001. National Institutes of Health. Principal Investigator. "Aging, Calorie Restriction, and Insulin Signaling," continuation. ($1,166,250).

1999. National Institutes of Health. Co-Investigator. "Dietary Restriction and Aging in Rhesus Monkeys," continuation. ($5,611,100).

1998. National Institutes of Health. Principal Investigator."Aging, Calorie Restriction, and Insulin Signaling." ($558,989).

1998. National Institutes of Health. Co-Investigator. "Dietary Restriction, mt DNA Abnormalities and Aging." ($549,739).

1994. National Institutes of Health. Co-Investigator. "Dietary Restriction and Aging in Rhesus Monkeys." ($4,541,955).

1992. National Institutes of Health. Principal Investigator. "Age Effects on Exercise-Stimulation of Glucose Transport." $480,293.

Links

• American College of Sports Medicine
• American Diabetes Association
• American Physiological Society
• Gerontological Society of America