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Gregory Cartee, Ph.D.

Interim Dean
Professor, Movement Science

• Areas of Interest
• Educational Background
• Research
• Teaching
• Honors and Awards
• Professional Affiliations and Service
• Selected Publications
• Selected Grants
• Links

4170 Observatory Lodge
1402 Washington Heights
Ann Arbor, MI 48109-2013

Executive Assistant: Marsha Lewis
mhlewis@umich.edu
Phone: (734) 764-5210
Fax: (734) 763-6283

Office Hours (Fall 2009):
Please call 734 764-5210 for appointment

Full vita>>

Laboratories / Research Centers:

• Muscle Biology Laboratory
• Center for Exercise Research
• Claude D. Pepper Older Americans Independence Center
• Nathan Shock Center of Excellence in Aging Research
• Institute of Gerontology
• Michigan Diabetes Research and Training Center
• Michigan Metabolomics and Obesity Center

Areas of Interest

Short Description: Exercise, diet, and age effects on insulin signaling and glucose metabolism in skeletal muscle

The research in the Muscle Biology Laboratory is focused on skeletal muscle metabolism. We are especially interested in the modulation of glucose transport by exercise and calorie restriction (consuming 60% of ad libitum uptake), and how these interventions are influenced by advancing age. Each of these interventions can lead to a substantial improvement in skeletal muscle insulin sensitivity, which is a significant benefit for health. The improved insulin sensitivity after a bout of exercise facilitates the restoration of muscle glycogen stores, thereby improving the capacity for subsequent exercise. Our long-term goals are to understand the specific mechanisms whereby these physiological interventions lead to improved insulin sensitivity.

Educational Background

Washington University School of Medicine, St. Louis, MO
Postdoctoral Fellowship, 1985-1988

University of Texas, Austin TX
Ph.D., Exercise Physiology, 1985
"The Effects of Age and Endurance Training on the Oxidative Metabolism of Fisher 344 Rats."

Florida State University, Tallahassee, FL
M.S., Exercise Physiology, 1981

University of Georgia, Athens, GA
B.S., Health and Physical Education, 1979

Research

• Mechanisms for Increased Insulin-Stimulated Glucose Transport after Acute Exercise
• Mechanisms for Improved Insulin Sensitivity with Calorie Restriction
• In Vitro Simulation of Calorie Restriction: Effects on Skeletal Muscle Insulin Signaling and Action

Teaching

MOVESCI 449 / KINESLGY 449.* Laboratory Rotation in Exercise Physiology

KINESLGY 545. Metabolic Responses to Exercise.
SYLLABUS

KINESLGY 600. Seminar in Movement Science

* Movement Science courses are for undergraduate credit; Kinesiology courses are for graduate credit.

Honors and Awards

Professional Affiliations and Service

Selected Publications

Publications in Refereed Journals

Funai K, Schweitzer GG, Sharma N, Kanzaki M, Cartee GD.  Increased AS160 phosphorylation, but not TBC1D1 phosphorylation, with increased postexercise insulin sensitivity in rat skeletal muscle.  Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E242-51.

Sharma N, Arias EB, Cartee GD.  Rapid reversal of insulin-stimulated AS160 phosphorylation in rat skeletal muscle after insulin exposure.  Physiol Res. 2009 Feb 27. [Epub ahead of print]

Funai K, Cartee GD.  Inhibition of contraction-stimulated AMP-activated protein kinase inhibits contraction-stimulated increases in PAS-TBC1D1 and glucose transport without altering PAS-AS160 in rat skeletal muscle.  Diabetes. 2009 May;58(5):1096-104.

Blair DR, Funai K, Schweitzer GG, Cartee GD.  A myosin II ATPase inhibitor reduces force production, glucose transport, and phosphorylation of AMPK and TBC1D1 in electrically stimulated rat skeletal muscle.  Am J Physiol Endocrinol Metab. 2009 May;296(5):E993-E1002.
 
Funai K, Cartee GD.  Contraction-stimulated glucose transport in rat skeletal muscle is sustained despite reversal of increased PAS-phosphorylation of AS160 and TBC1D1.  J Appl Physiol. 2008 Dec;105(6):1788-95.

Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA.  A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.  PLoS One. 2008 Jun 4;3(6):e2264.

Arias EB, Cartee GD.  In vitro simulation of calorie restriction-induced decline in glucose and insulin leads to increased insulin-stimulated glucose transport in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1782-8.

Cartee GD, Wojtaszewski JF.  Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport.  Appl Physiol Nutr Metab. 2007 Jun;32(3):557-66.

Arias EB, Kim J, Funai K, Cartee GD. Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle.  Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1191-200.

Selected Grants

Extramural:

2007. National Institutes of Health. Principal Investigator. “Aging, Calorie Restriction and Insulin Signaling.” ($1,541,912).

2007. National Institutes of Health. Principal Investigator. “Aging, Calorie Restriction and Insulin Signaling.” Supplement ($76,000).

2006. National Institutes of Health. Principal Investigator. “Skeletal Muscle Glucose Transport: Exercise and Insulin.” ($1,532,000).

2004. National Institutes of Health. Principal Investigator. "In Vitro Models for Insulin sensitivity in Rat Skeletal Muscle: Pilot Project." (Claude Pepper Older American's Independence Center. Jeffrey Halter, MD., PI). ($40,000).

2001. National Institutes of Health. Principal Investigator. "Aging, Calorie Restriction, and Insulin Signaling," continuation. ($1,166,250).

1999. National Institutes of Health. Co-Investigator. "Dietary Restriction and Aging in Rhesus Monkeys," continuation. ($5,611,100).

1998. National Institutes of Health. Principal Investigator."Aging, Calorie Restriction, and Insulin Signaling." ($558,989).

1998. National Institutes of Health. Co-Investigator. "Dietary Restriction, mt DNA Abnormalities and Aging." ($549,739).

1994. National Institutes of Health. Co-Investigator. "Dietary Restriction and Aging in Rhesus Monkeys." ($4,541,955).

1992. National Institutes of Health. Principal Investigator. "Age Effects on Exercise-Stimulation of Glucose Transport." $480,293.

Links

• American College of Sports Medicine
• American Diabetes Association
• American Physiological Society
• Gerontological Society of America