Gregory Cartee, Ph.D.
Professor, Movement Science
4745F CCRB
401 Washtenaw Ave.
Ann Arbor, MI 48109-2214
Phone: (734) 615-3458
Fax: (734) 936-1925
gcartee@umich.edu
Office Hours (Spring Summer 2008):
Please contact for an appointment
Full vita>>
Laboratories / Research Centers:
Areas of Interest
Short Description: Exercise, diet, and age effects on insulin signaling and glucose metabolism in skeletal muscle
The research in the Muscle Biology Laboratory is focused on skeletal muscle metabolism. We are especially interested in the modulation of glucose transport by exercise and calorie restriction (consuming 60% of ad libitum uptake), and how these interventions are influenced by advancing age. Each of these interventions can lead to a substantial improvement in skeletal muscle insulin sensitivity, which is a significant benefit for health. The improved insulin sensitivity after a bout of exercise facilitates the restoration of muscle glycogen stores, thereby improving the capacity for subsequent exercise. Our long-term goals are to understand the specific mechanisms whereby these physiological interventions lead to improved insulin sensitivity.
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Educational Background
Washington University School of Medicine, St. Louis, MO
Postdoctoral Fellowship, 1985-1988
University of Texas, Austin TX
Ph.D., Exercise Physiology, 1985
"The Effects of Age and Endurance Training on the Oxidative Metabolism of Fisher 344 Rats."
Florida State University, Tallahassee, FL
M.S., Exercise Physiology, 1981
University of Georgia, Athens, GA
B.S., Health and Physical Education, 1979
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Research

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Teaching
MOVESCI 449 / KINESLGY 449.* Laboratory Rotation in Exercise Physiology
KINESLGY 545. Metabolic Responses to Exercise.
SYLLABUS
KINESLGY 600. Seminar in Movement Science
* Movement Science courses are for undergraduate credit; Kinesiology courses are for graduate credit.
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Honors and Awards
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Fellow, American Academy for Kinesiology and Physical Education (AAKPE) |
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2003
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Research Fellowship, Japan Society for the Promotion of Science (July 21 — August 7, 2003)
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2002
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Wenner-Gren Center Visiting Scientist, Karolinska Institute, Stockholm, Sweden
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1998
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Fellow, American College of Sports Medicine
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1987
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National Research Service Award, The National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
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1983
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Professional Development Award, University of Texas at Austin
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Professional Affiliations and Service
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Affiliations
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American College of Sports Medicine
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American Diabetes Association
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American Physiological Society
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Gerontological Society of America
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Editorial Responsibilities for Professional Journals
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American Journal of Physiology: Endocrinology and Metabolism (Editorial Board, 2007-2009) |
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Exercise and Sports Sciences Reviews (Associate Editor, 2000-2007)
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Journal of Applied Physiology (Associate Editor, 1999-2001)
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Journal of Gerontology: Biological Sciences (Editorial Review Board, 1998-1999)
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Reviewer for Professional Journals:
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American Journal of Physiology: Cell Physiology
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American Journal of Physiology: Endocrinology and Metabolism
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American Journal of Physiology: Lung Cellular and Molecular Physiology
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American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
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Diabetes
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Diabetologia
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Experimental Gerontology
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Exercise and Sport Sciences Reviews
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FASEB Journal
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Hormones and Behavior
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The International Journal of Biochemistry & Cell Biology
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International Journal of Obesity
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International Journal of Sports Medicine
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Journal of the American College of Nutrition
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Journal of Applied Physiology
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Journal of Endocrinology
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Journal of Nutrition
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Journal of the American College of Nutrition
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Life Sciences
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Mechanisms of Ageing and Development
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Medicine and Science in Sports and Exercise
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Molecular and Cellular Biochemistry
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Obesity Research
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Proceedings of National Academy of Sciences, U.S.A.
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The International Journal of Biochemistry & Cell Biology
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The Journal of Physiology
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The Journals of Gerontology: Biological and Medical Sciences
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Grant Review Responsibilities
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National Institutes of Health (Skeletal Muscle Biology and Exercise Physiology Study Section), Regular Member, 2001-2005 and 2006-2009 |
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Skeletal Muscle Biology and Exercise Physiology Study Section, Regular Member, 2001-2005 |
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University Service
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Executive Committee, Division of Kinesiology, 2004-2007 |
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Nathan Shock Center Internal Advisory Committee, 2005-2007 |
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Selected Publications
Publications in Refereed Journals
Arias, E.B and G.D. Cartee. “In vitro simulation of calorie restriction-induced decline in glucose and insulin leads to increased insulin-stimulated glucose transport in rat skeletal muscle.” Am. J. Physiol.(Endocrinol. Metab.). 293: E1782-E1788, 2007.
Arias, E.B., J. Kim, K. Funai and G.D. Cartee. “Prior exercise increases Akt Substrate of 160 kDa
phosphorylation in rat skeletal muscle”. Am. J. Physiol. (Endocrinol. Metab.) 292: E1191-E1200, 2007.
Cartee, G.D. and J.F. Wojtaszewski. “Role of Akt Substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport”. Appl. Physiol, Nutr. Metab. 32: 557-556, 2007.
Kim, J., E.B. Arias and G.D. Cartee. “Effects of prior swim exercise on glucose uptake in isolated skeletal muscles from mice,” J. Physiol. Sci. 56: 305-312, 2006.
Hamada, T., E.B. Arias and G.D. Cartee. “Increased submaximal insulin-stimulated glucose uptake in mouse skeletal muscle after treadmill exercise.” J. Appl. Physiol. 101: 1368-1376, 2006.
Bruss, M.D., E.B. Arias, G.E. Lienhard, and G.D. Cartee. "Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity." Diabetes. 54: 41-50, 2005.
McCurdy, C.E, R.T. Davidson and G.D. Cartee. "Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle." Am. J. Physiol.(Endocrinol. Metab.). 288: E996-E1001, 2005.
McCurdy, C.E. and G.D. Cartee. "Akt2 is essential for the full effect of calorie restriction on insulin-stimulated glucose uptake in skeletal muscle." Diabetes. 54: 1349-1356, 2005.
Sancho, R., J. Kim and G.D. Cartee. "Decreased contraction-stimulated glucose transport in isolated epitrochlearis muscles of pregnant rats". J. Appl. Physiol. 98: 1021-1027, 2005.
Kim, J., R.S. Solis, E.B. Arias, and G.D. Cartee. "Post-contraction insulin sensitivity: Relationship with contraction protocol, glycogen concentration and 5'AMP-activated protein kinase phosphorylation". J. Appl. Physiol. 96: 575-583, 2004.
Arias, E.B., J. Kim, and G.D. Cartee. "Prolonged incubation in PUGNAC results in increased protein O-linked glycosylation and insulin resistance in rat skeletal muscle". Diabetes. 53: 921-930, 2004.
McCurdy, C.E., R.T. Davidson, and G.D. Cartee. "Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle". Am. J. Physiol.(Endocrinol. Metab.) 48: E693-E700, 2003.
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Selected Grants
Extramural:
2007. National Institutes of Health. Principal Investigator. “Aging, Calorie Restriction and Insulin Signaling.” ($1,541,912).
2007. National Institutes of Health. Principal Investigator. “Aging, Calorie Restriction and Insulin Signaling.” Supplement ($76,000).
2006. National Institutes of Health. Principal Investigator. “Skeletal Muscle Glucose Transport: Exercise and Insulin.” ($1,532,000).
2004. National Institutes of Health. Principal Investigator. "In Vitro Models for Insulin sensitivity in Rat Skeletal Muscle: Pilot Project." (Claude Pepper Older American's Independence Center. Jeffrey Halter, MD., PI). ($40,000).
2001. National Institutes of Health. Principal Investigator. "Aging, Calorie Restriction, and Insulin Signaling," continuation. ($1,166,250).
1999. National Institutes of Health. Co-Investigator. "Dietary Restriction and Aging in Rhesus Monkeys," continuation. ($5,611,100).
1998. National Institutes of Health. Principal Investigator."Aging, Calorie Restriction, and Insulin Signaling." ($558,989).
1998. National Institutes of Health. Co-Investigator. "Dietary Restriction, mt DNA Abnormalities and Aging." ($549,739).
1994. National Institutes of Health. Co-Investigator. "Dietary Restriction and Aging in Rhesus Monkeys." ($4,541,955).
1992. National Institutes of Health. Principal Investigator. "Age Effects on Exercise-Stimulation of Glucose Transport." $480,293.
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Links
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