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TitleFabry disease in mice is associated with age-dependent susceptibility to vascular thrombosis
Publication TypeJournal Article
Year of Publication2003
AuthorsEitzman, D. T., Bodary P. F., Shen Y., Khairallah C. G., Wild S. R., Abe A., Shaffer-Hartman J., & Shayman J. A.
JournalJournal of the American Society of Nephrology: JASN
Volume14
Issue2
Pagination298 - 302
Date Published2003/02//
ISBN Number1046-6673
KeywordsAging, Animals, Bone Marrow Transplantation, Carotid Arteries, Carotid Artery Diseases, Disease Susceptibility, Fabry Disease, Mice, Mice, Knockout, Thrombosis, Trihexosylceramides
Abstract

Fabry disease is an X-linked lysosomal storage disorder due to deficiency of alpha-galactosidase A (GLA) activity that results in the widespread accumulation of neutral glycosphingolipids. Renal failure, neuropathy, premature myocardial infarction, and stroke occur in patients with this condition primarily due to deposition of glycosphingolipids in vascular endothelial cells. The clinical consequences of Fabry disease suggest that vascular thrombosis may play a prominent role in the pathogenesis of this disease; however, the vasculopathy associated with Fabry disease has not been extensively studied. To determine if mice genetically deficient in Gla are susceptible to vascular thrombosis, a photochemical carotid injury model was used to induce occlusive thrombosis. In this model, Gla-/0 mice displayed a progressive age-dependent shortening of the time to occlusive thrombosis after vascular injury that correlated with progressive accumulation of globotriasylceramide (Gb3) in the arterial wall. Bone marrow transplantation from Gla-/0 to Gla+/0 mice and from Gla+/0 to Gla-/0 mice did not change the thrombotic phenotype of the host. These studies reveal a potent vascular prothrombotic phenotype in Gla-deficient mice and suggest that antithrombotic therapies as well as therapies designed to reduce the vascular accumulation of Gb3 may have beneficial effects on thrombotic complications in patients with Fabry disease.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/12538729

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