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TitleExercise and insulin: Convergence or divergence at AS160 and TBC1D1?
Publication TypeJournal Article
Year of Publication2009
AuthorsCartee, G. D., & Funai K.
JournalExercise and Sport Sciences Reviews
Pagination188 - 195
Date Published2009/10//
ISBN Number1538-3008
KeywordsAnimals, Glucose Transporter Type 4, GTPase-Activating Proteins, Insulin, Mice, Muscle Contraction, Muscle, Skeletal, Physical Conditioning, Animal, Proteins, Rats

Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport.


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