Although 30 million individuals are engaged in fantasy sports games in the United States, little is known about the personality, attitudes, and intentions of fantasy sports game participants. This study (N = 244) explored the role of gender, sensation seeking (SS), locus of control (LOC), and need for cognition (NFC) in predicting attitudes and intentions relative to participating in fantasy football league. A domain-specific construct (e.g., perceived football knowledge: PK) was employed as a moderator to control the potential attenuating effects of personality and related human behavior. A moderated multiple regression technique (MMR) examined the first-order and lower-order interaction effects on attitudes and behavioral intentions toward fantasy games. For males (n = 123), SS, LOC, and PK were related to both attitudes and intentions toward participating and PK acted as a moderator between LOC and intentions. For females (n = 121), none of the personality traits was associated with attitudes or intentions. The applied and theoretical implications of the findings are discussed along with future directions for research.