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TitleEffect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults
Publication TypeJournal Article
Year of Publication2004
AuthorsBrook, R. D., Bard R. L., Glazewski L., Kehrer C., Bodary P. F., Eitzman D. L., & Rajagopalan S.
JournalThe American Journal of Cardiology
Pagination1012 - 1016
Date Published2004/04/15/
ISBN Number0002-9149
KeywordsAdolescent, Adult, Anti-Obesity Agents, C-Reactive Protein, Cholesterol, LDL, Diet, Reducing, Endothelium, Vascular, Female, Humans, Insulin, Lactones, Leptin, Lipoproteins, LDL, Male, Metabolic Syndrome X, Middle Aged, Obesity, Weight Loss

Impaired vascular endothelial function may be an important mechanism linking obesity to increased cardiovascular risk. We investigated whether short-term weight loss improves conduit artery endothelial dysfunction in overweight adults. Forty-three otherwise healthy overweight patients with a body mass index > or =27 kg/m(2) completed an open-label 3-month trial consisting of a calorie-restricted diet and 120 mg of orlistat taken 3 times daily with meals. Endothelial function and parameters of the metabolic syndrome were measured before and after intervention. Subjects lost 6.6 +/- 3.4% of their body weight. Low-density lipoprotein cholesterol, low-density lipoprotein concentration, fasting insulin, and leptin decreased significantly (all p <0.009), and C-reactive protein decreased (p = 0.22). Conduit vascular function did not change as assessed by flow-mediated dilation (3.86 +/- 3.54 vs 3.74 +/- 3.78%, p = 0.86) and nitroglycerin-mediated dilation (17.18 +/- 5.89 vs 18.87 +/- 7.11%, p = 0.13) of the brachial artery. A moderate degree of weight reduction over 3 months improved the metabolic syndrome profile but not the vascular dysfunction associated with uncomplicated obesity.


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